ISSN : 2348 - 8948

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Volume : 5 Issue :12 Month : December (2017)
Page Numbers : 508-512

Pharmacological Evaluation Of Anti-Depressant Activity Of Linum Usitatissimum In Mice Model

R Naga Kishore
Objective: The present study was designed to investigate the anti-depressant activity of the Linum usitatissimum. Methods: Anti-depressant activity is evaluated by forced swim test, tail suspension test and open field test. Healthy albino mice (6-7 week old) weighing 20-40 grams were used. Potency of the test sample was compared with the standard fluoxetine drug. Results: Results showed that the administration of the Linum usitatissimum produced adiminution of immobility time in mice exposed to the both forced swimming and tail suspension tests. In the present study, Linum usitatissimum (100mg/kg) administered to mice, produced significant anti-depressant like effect in both TST and FST and efficacy was found to be comparable to fluoxetine (20 mg/kg, ip). Conclusion: Further studies would be necessary to evaluate the contribution of Linum usitatissimum for the ob-served anti-depressant activity as it still remains to be determined for the side effects.
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