ISSN : 2348 - 8948

Current Issue

Volume : 5 Issue :12 Month : December (2017)
Page Numbers : 429-441

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR COMBINATION OF CEFUROXIME AXETIL AND LINEZOLID IN PHARMACEUTICAL DOSAGE FORM

Nikita Patel*, Ishita Mehta, Dr.Chirag Patel, Dr. M. M. Patel
A simple, rapid, accurate and economical RP-HPLC method has been developed for simultaneous estimation of Cefuroxime Axetil& Linezolid pharmaceutical dosage validated as per ICH guideline.For the analysis, HPLC LC- 20 AT SPD 20A UV detector at 240 nm and C18 (250mm x 4.6 mm) column was used. The selected mobile phase was Potassium phosphate (pH 5.0) and Acetonitrile (60:40v/v) in isocratic mode at a flow rate of 1 mL/min. Retention time of Linezolid and Cefuroxime Axetil were found to be 3.713 min and 6.107 min respectively.
 
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