ISSN : 2348 - 8948

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Volume : 5 Issue :12 Month : December (2017)
Page Numbers : 456-466

Stability Indicating Method For The Simultaneous Estimation Of Cefuroxime Axetil And Linezolid In Pharmaceutical Dosage Forms

Nikita Patel*, Ishita Mehta, Dr.Chirag Patel, Dr. M. M. Patel
A simple, rapid, accurate and economical stability indicating RP-HPLC method has been developed for simultaneous estimation of Cefuroxime Axetil & Linezolid pharmaceutical dosage under different stress conditions For the analysis, HPLC LC- 20 AT SPD 20A UV detector at 240 nm and C18 (250mm x 4.6 mm) column was used. The selected mobile phase was Potassium phosphate (pH 5.0) and Acetonitrile (60:40v/v) in isocratic mode at a flow rate of 1 mL/min. Retention time of Linezolid and Cefuroxime Axetil were found to be 3.713 min and 6.107 min respectively. The methods are found to be specific as there was no interference of any co-eluting impurities after stress degradation study. The degraded products are well resolved, indicating the method can also be useful for determination of degraded products.
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