ISSN : 2348 - 8948

Current Issue

Volume : 5 Issue :6 Month : June (2017)
Page Numbers : 204-211

COMPARATIVE QUALITY EVALUATION OF MARKETED FORMULATION OF DICLOFENAC DIETHYLAMINE GEL

Vrushika R. Khairnar*, Vipul P. patel , Laxman P. Gorde
Diclofenac diethylamine (DDA), a non-steroidal anti-inflammatory agent is frequently prescribed for the long term treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Three different marketed DDA gel formulations of different brands were evaluated to check their critical quality control parameters. Different brands of formulations were characterized for their drug diffusion study, texture analysis profile, viscosity, pH etc. The statistical methods like correlation coefficient, confidence interval (95% CI) were applied for their dosage form performance aspect in comparision with reference product.The results of all three brands revealed that Brand B is superior to Brand A and Brand C in terms of drug diffusion properties (96.8%, 50min) in comparision with reference product profile, texture analysis (TPA-450 and Compresion- 550) and viscosity (2300cP).
 
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